Endocrine Abstracts

The empty sella syndrome (ESS) is caused by the herniation of the suprarahnoidian space into the sella turcica, generating the compression of the pituitary gland and, in most cases, a remodelling of the sella. The purpose of this study was to evaluate the etiology, the degree of hormonal deficit and the occurrence rate of the signs and symptoms accompanying ESS.Material and methods: We performed a descriptive, retrospective study by analysing the medical...

Purpose: Osteopathy/osteoporosis in Gaucher disease type 1 (GD1) shows variable responses to enzyme replacement therapy (ERT); the pathogenesis is incompletely understood. We aimed to investigate the effect of several gene variants on bone mineral density (BMD) and serum markers of bone metabolism in GD1.Patients/methods: 50 adult Caucasian patients with GD1/117 controls were genotyped for gene variants in the osteoprotegerin (TNFRSF11B; OPG), estrogen r...

Introduction: Type 1 diabetes secondary osteoporosis is an underdiagnosed condition and there are few studies that addressed the topic of clinical risk factors in this context, although, for a better diagnosis and management, it is of great importance to find such predictors.Aim: To evaluate bone mineral density and parameters of bone metabolism in patients with type 1 diabetes in comparison with a group of healthy subjects and to determine possible risk...

One of the causes of secondary osteoporosis is type 1 DM (1DM), an autoimmune disease where insulin replacement is mandatory for controlling blood sugar levels. Among the mechanisms involved in osteoporosis in 1DM is increased bone resorption, mainly osteoclasts being responsible for this process. However, osteoblasts also seem to have an active contribution by secreting products with resorptive properties, one of these being cysteine protease Cathepsin K, as mentioned by a fe...